The Laboratory of Multiscale Bioimaging (LMB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell.
Lab News & Scientific Highlights
Dynamical transitions in dense packings
Biophysical modeling points to changes in collective dynamics under confinement as a key aspect of cell state transitions.
Breast cancer classification using AI
Researchers at PSI and MIT are developing a new approach, which combines imaging and artificial intelligence to improve the staging of breast cancer.
Protein droplets likely don’t cause Parkinson’s
Study deepens our understanding of neurodegenerative diseases linked to protein aggregation.
Publications
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Chen Y, Sun X, Tang Y, Tan Y, Guo C, Pan T, et al.
Pathogenic mutation ΔK280 promotes hydrophobic interactions involving microtubule-binding domain and enhances liquid-liquid phase separation of tau
Small. 2025; 21(6): 2406429 (12 pp.). https://doi.org/10.1002/smll.202406429
DORA PSI -
Aidukas T, Phillips NW, Diaz A, Poghosyan E, Müller E, Levi AFJ, et al.
High-performance 4-nm-resolution X-ray tomography using burst ptychography
Nature. 2024; 632(8023): 81-88. https://doi.org/10.1038/s41586-024-07615-6
DORA PSI -
Asmara TC, Green RJ, Suter A, Wei Y, Zhang W, Knez D, et al.
Emergence of interfacial magnetism in strongly‐correlated nickelate‐titanate superlattices
Advanced Materials. 2024; 36(38): 2310668 (14 pp.). https://doi.org/10.1002/adma.202310668
DORA PSI -
Braunger JM, Cammarata LV, Sornapudi TR, Uhler C, Shivashankar GV
Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging
Aging cell. 2024; 23(3): e14056 (18 pp.). https://doi.org/10.1111/acel.14056
DORA PSI -
Cellini A, Shankar MK, Nimmrich A, Hunt LA, Monrroy L, Mutisya J, et al.
Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Nature Chemistry. 2024; 16: 624-632. https://doi.org/10.1038/s41557-023-01413-9
DORA PSI
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